Association studies for asthma and atopic diseases: a comprehensive review of the literature
نویسندگان
چکیده
Hundreds of genetic association studies on asthma-related phenotypes have been conducted in different populations. To date, variants in 64 genes have been reported to be associated with asthma or related traits in at least one study. Of these, 33 associations were replicated in a second study, 9 associations were not replicated either in a second study or a second sample in the same study, and 22 associations were reported in just a single published study. These results suggest the potential for a great amount of heterogeneity underlying asthma. However, many of these studies are methodologically limited and their interpretation hampered by small sample sizes.
منابع مشابه
Comorbidities of pediatric asthma: A narrative review
Background: Asthma is one of the most common persistent inflammatory respiratory disorders. Comorbidities are relatively common in asthma. The aim of this review study was to find comorbid disorders in children with asthma. Methods: For the purpose of this review, we searched databases including Scopus, Google scholar, PubMed, SID, Irandoc and up-to-date. Key words for the search included chil...
متن کاملIs There any Possible Association Between Trimethylamine N-Oxide (TMAO) and Cancer? A Review Study
Background: During the transit of digested animal source foods, gut microbiota synthesize metabolites that can affect the body cells. One of these metabolites, i.e. Trimethylamine (TMA) that is an intermediary metabolite, ultimately leads to the production of Trimethylamine N-oxide (TMAO). Several studies have been conducted to show the association between TMAO and different diseases. This arti...
متن کاملThe Relationship Between Maternal Vitamin E and Progress of Children Asthma: A Review Article
Asthma is a chronic inflammatory respiratory disease. Nutritional conditions effects on allergic diseases such as asthma. The aim of this study is to find relation of maternal vitamin E and progression of children asthma. This is a review article searched in data base include Google, PubMed, SID, Irandoc, Scopus and up-to-date. Key words for search include maternal vitamin e, asthma, children ...
متن کاملIs there any Association Between Human Lymphotropic Virus Type I (HTLV-I) Infection and Systemic Lupus Erythematosus? An Original Research and Literature Review
متن کامل
Asthma and lung cancer, after accounting for co-occurring respiratory diseases and allergic conditions: a systematic review protocol
INTRODUCTION Asthma is one of the most frequently diagnosed respiratory diseases in the UK, and commonly co-occurs with other respiratory and allergic diseases, such as chronic obstructive pulmonary disease (COPD) and atopic dermatitis. Previous studies have shown an increased risk of lung cancer related to asthma, but the evidence is mixed when accounting for co-occurring respiratory diseases ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Respiratory Research
دوره 4 شماره
صفحات -
تاریخ انتشار 2003